Serum monitoring of carbamazepine in patients with epilepsy and clinical implications

Carbamazepine is a drug with narrow therapeutic range that requires clinical monitoring, since its toxic effects are not easily predictable, and the level can vary. Our study aimed to monitor serum determine concentration/dose relationship of carbamazepine in people epilepsy, analyzing implication. It observed 90.48% volunteers present values (4.3–10.4 mg/L) within (4–12 mg/L); 7.14% supratherapeutic levels (12.7–14.4 mg/L), 2.38% subtherapeutic (0.93 mg/L). The findings indicate negative correlation (r = -0.616; r 2 0.379; p 0.001), between dose (mg/day) ratio (mg/L/mg/day); positive 0.544; 0.296; 0.002), (mg/day)-serum concentration (mg/L). ANOVA Tukey’s test mean difference significant (p<0.05). concluded there linear daily doses concentrations, which should be considered individualize optimize results.